Darkening of the skin in certain areas may also occur. Symptoms generally come on slowly and insidiously and may include abdominal pain and gastrointestinal abnormalities, weakness, and weight loss. Synthetic Corticosteroid such as hydrocortisone and fludrocortisone Ġ.9–1.4 per 10,000 people (developed world) Īddison's disease, also known as primary adrenal insufficiency, is a rare long-term endocrine disorder characterized by inadequate production of the steroid hormones cortisol and aldosterone by the two outer layers of the cells of the adrenal glands ( adrenal cortex), causing adrenal insufficiency. Addison disease, primary adrenal insufficiency, primary adrenocortical insufficiency, chronic adrenal insufficiency, chronic adrenocortical insufficiency, primary hypocorticalism, primary hypocortisolism, primary hypoadrenocorticism, primary hypocorticism, primary hypoadrenalismĭarkening of the skin seen on the legs of a patient with an excess of melanin.Ībdominal pain, weakness, weight loss, darkening of the skin īlood tests, urine tests, medical imaging
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